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Quad-Mix

Quad-Mix is a compounded prescription injection that generally combines alprostadil (prostaglandin E1), papaverine, phentolamine, and atropine. A urology prescriber may consider it for erectile dysfunction after reviewing other options, prior response, and individual risks.

Healing Dose Compounding Pharmacy in Farmington Hills, Michigan, can confirm the exact formula on your prescription, availability, pricing, and dispensing instructions. Injection training and an individualized dose are required.

This medication requires a prescription.

Additional Information

What is Quad-Mix?

Quad-Mix, also searched as Quadmix or Quad Mix injection, is a compounded intracavernosal medication. The name generally refers to four ingredients: alprostadil (prostaglandin E1), papaverine, phentolamine, and atropine. The prescription must specify each ingredient and concentration. Formulas and dose volumes can differ between pharmacies and prescriptions.

When might a prescriber consider it?

A urology clinician may consider injection therapy for diagnosed erectile dysfunction when oral medication is unsuitable, not tolerated, or has not provided an adequate response. Evaluation may include vascular, neurologic, medication-related, diabetes-related, or post-prostate-treatment factors. These conditions do not automatically make Quad-Mix appropriate; the clinician selects treatment after reviewing the individual’s health and goals.

How does Quad-Mix differ from Tri-Mix?

Tri-Mix commonly combines alprostadil, papaverine, and phentolamine. Quad-Mix generally adds atropine. Names such as “Super” or “Mega” are not standardized doses. Do not substitute one formula for another or reuse a prior injection volume without instructions from your prescriber.

What does research say about injection therapy?

The American Urological Association’s erectile dysfunction guideline includes intracavernosal injections among options to discuss with patients and recommends an in-office injection test for patients considering treatment. This supports discussion of injection therapy as a treatment category; it does not establish that a specific Quad-Mix formula is superior or suitable for every patient.

Reference: Burnett AL, et al. Erectile Dysfunction: AUA Guideline. Journal of Urology. 2018. Read the journal article.

What should I know before using a prescription injection?

Receive hands-on instruction and an individualized written plan from your clinician. Discuss bleeding disorders or blood thinners, prior prolonged erections, penile scarring or curvature, and all ED medications. Risks include injection-site discomfort, bruising, scarring, and a prolonged erection. Seek emergency medical care for an erection lasting four hours or longer; follow your clinician’s instructions for earlier intervention. Do not rely on home measures to delay urgent care.

Do I need a prescription, and how do I order?

Yes. A valid patient-specific prescription is required. Contact Healing Dose Compounding Pharmacy in Farmington Hills, Michigan, at (855) 728-0288 to confirm ingredients, concentrations, supplies, pricing, availability, and shipping eligibility. Follow the dispensing label for storage and beyond-use date. Compounded medications are not FDA-approved and are not reviewed by FDA for safety, effectiveness, or quality before marketing.

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Related prescription options to discuss with your clinician

Related products are educational comparisons, not a recommendation to combine therapies. Do not add another ED medicine unless your prescriber specifically directs you to do so.

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The formulas and/or statements listed are provided for educational purposes only. They are compounding ideas that have commonly been requested by physicians, and have not been evaluated by the Food and Drug Administration. Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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