Compounded T3/T4 with Methylcellulose (E4M) may be prescribed when a provider wants customized Thyroxine (T4) and Triiodothyronine (T3) strengths or ratios in one formulation. Prescription required.
Compounded T3/T4 with Methylcellulose (E4M) is a prescription formulation prepared at a prescriber’s discretion to support individualized thyroid hormone supplementation. It combines Thyroxine (T4) and Triiodothyronine (T3) in customized strengths and ratios based on patient-specific needs.
The E4M (methylcellulose) base is commonly selected when a provider is requesting a more controlled release profile, which may help support more consistent dosing throughout the day. Compounding can also be useful when commercially available products don’t match a requested ratio, dosage strength, or excipient preference.
This formulation may be appropriate for patients who need a hypoallergenic approach or who prefer to avoid certain common additives. To learn more about thyroid-related compounding options, see thyroid disease.
